Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms

Y Wang, G Zhan, Z Cai, B Jiao, Y Zhao, S Li… - … & Biobehavioral Reviews, 2021 - Elsevier
Brain diseases, including neurodegenerative, cerebrovascular and neuropsychiatric
diseases, have posed a deleterious threat to human health and brought a great burden to …

A review of parameter settings for invasive and non-invasive vagus nerve stimulation (VNS) applied in neurological and psychiatric disorders

SL Thompson, GH O'Leary, CW Austelle… - Frontiers in …, 2021 - frontiersin.org
Vagus nerve stimulation (VNS) is an established form of neuromodulation with a long history
of promising applications. Earliest reports of VNS in the literature date to the late 1800's in …

[HTML][HTML] How to fail with paired VNS therapy

SA Hays, RL Rennaker II, MP Kilgard - Brain stimulation, 2023 - Elsevier
Vagus nerve stimulation (VNS) has gained enormous traction as a promising bioelectronic
therapy. In particular, the delivery of VNS paired with training to promote neural changes has …

Rapid effects of vagus nerve stimulation on sensory processing through activation of neuromodulatory systems

C Rodenkirch, JB Carmel, Q Wang - Frontiers in neuroscience, 2022 - frontiersin.org
After sensory information is encoded into neural signals at the periphery, it is processed
through multiple brain regions before perception occurs (ie, sensory processing). Recent …

Direct and transcutaneous vagus nerve stimulation for treatment of tinnitus: A scoping review

N Yakunina, EC Nam - Frontiers in Neuroscience, 2021 - frontiersin.org
Recent animal research has shown that vagus nerve stimulation (VNS) paired with sound
stimuli can induce neural plasticity in the auditory cortex in a controlled manner. VNS paired …

[HTML][HTML] Vagus nerve stimulation must occur during tactile rehabilitation to enhance somatosensory recovery

AD Ruiz, KM Malley, TT Danaphongse, FN Ahmad… - Neuroscience, 2023 - Elsevier
Chronic sensory loss is a common and undertreated consequence of many forms of
neurological injury. Emerging evidence indicates that vagus nerve stimulation (VNS) …

High intensity VNS disrupts VNS-mediated plasticity in motor cortex

RA Morrison, TT Danaphongse, ST Abe, ME Stevens… - Brain research, 2021 - Elsevier
Vagus nerve stimulation (VNS) paired with motor rehabilitation enhances recovery of
function after neurological injury in rats and humans. This effect is ascribed to VNS …

Exploring the potential of vagus nerve stimulation in treating brain diseases: a review of immunologic benefits and neuroprotective efficacy

Z Jin, J Dong, Y Wang, Y Liu - European Journal of Medical Research, 2023 - Springer
The vagus nerve serves as a critical connection between the central nervous system and
internal organs. Originally known for its effectiveness in treating refractory epilepsy, vagus …

New tools for shaping plasticity to enhance recovery after stroke

F Motolese, F Capone, V Di Lazzaro - Handbook of clinical neurology, 2022 - Elsevier
Stroke is the second most common cause of death worldwide and its prevalence is projected
to increase in the coming years in parallel with the increase of life expectancy. Despite the …

Vagus nerve stimulation as a potential adjuvant to rehabilitation for post-stroke motor speech disorders

RA Morrison, SA Hays, MP Kilgard - Frontiers in Neuroscience, 2021 - frontiersin.org
Stroke often leaves lasting impairments affecting orofacial function. While speech therapy is
able to enhance function after stroke, many patients see only modest improvements after …