The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

Despite being the subject of extensive research and clinical trials, neuroblastoma remains a
major therapeutic challenge in pediatric oncology. The p53 protein is a central safeguard …

Annotation of prostate cancer genomes provides a foundation for discoveries that can
impact disease understanding and treatment. Concordant assessment of DNA copy number …

The really interesting genes (RING)-finger-containing oncoprotein, Mdm2, is a promising
drug target for cancer therapy. A key Mdm2 function is to promote ubiquitylation and …

Deletion of 3p13 has been reported from about 20% of prostate cancers. The clinical
significance of this alteration and the tumour suppressor gene (s) driving the deletion remain …

Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial
developmental and physiological processes in the cell. More recently, they have been found …

Inactivation of the tumor suppressor p53 and/or overexpression of the oncogene MDM2
frequently occur in human cancers, and are associated with poor prognosis, advanced forms …

ABSTRACT Yin Yang 1 (YY1) is a transcription factor with diverse and complex biological
functions. YY1 either activates or represses gene transcription, depending on the stimuli …

Background Depletion of certain ribosomal proteins induces p53 activation, which is
mediated mainly by ribosomal protein L5 (RPL5) and/or ribosomal protein L11 (RPL11) …

Low temperature stress represents a major threat to the lives of both farmed and wild fish
species. However, biological pathways determining the development of cold resistance in …