In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

The role of alternate DNA conformations such as Z-DNA in the regulation of transcription is
currently underappreciated. These structures are encoded by sequences called flipons …

Osteoarthritis is the most common degenerative joint disorder. MicroRNAs are gene
expression regulators that act post-transcriptionally to control tissue homeostasis. Microarray …

The metazoan-specific Integrator complex is a> 1.5 MDa machinery that interacts with RNA
polymerase II (RNAP2) to attenuate coding gene transcription by early termination close to …

In animals, microRNA (miRNA) biogenesis begins with cotranscriptional cleavage of the
primary (pri-) miRNA by the Microprocessor complex. Cotranscriptional splicing has been …

Integrator is a multi-subunit protein complex responsible for premature transcription
termination of coding and non-coding RNAs. This is achieved via two enzymatic activities …

Repressor element-1 silencing transcription factor (REST) is required for the formation of
mature neurons. REST dysregulation underlies a key mechanism of neurodegeneration …

SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of
XPO1 inhibitors, selinexor and eltanexor, in high-risk myelodysplastic neoplasms (MDS) …

Sepsis is a severe medical condition distinguished by immune systematic dysfunction and
multiple organic injury, or even failure, resulting from an acute systemic inflammatory …

Dysregulation of long non-coding RNA (lncRNA) HOXA-AS3 has been shown to contribute
to the development of multiple cancer types. Several studies have presented the tumour …