Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
SA Welsh, A Gardini - Nature Reviews Molecular Cell Biology, 2023 - nature.com
In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …
Flipons and small RNAs accentuate the asymmetries of pervasive transcription by the reset and sequence-specific microcoding of promoter conformation
A Herbert - Journal of Biological Chemistry, 2023 - ASBMB
The role of alternate DNA conformations such as Z-DNA in the regulation of transcription is
currently underappreciated. These structures are encoded by sequences called flipons …
currently underappreciated. These structures are encoded by sequences called flipons …
MicroRNA signatures in cartilage ageing and osteoarthritis
P Balaskas, K Goljanek-Whysall, PD Clegg, Y Fang… - Biomedicines, 2023 - mdpi.com
Osteoarthritis is the most common degenerative joint disorder. MicroRNAs are gene
expression regulators that act post-transcriptionally to control tissue homeostasis. Microarray …
expression regulators that act post-transcriptionally to control tissue homeostasis. Microarray …
[HTML][HTML] Take a break: Transcription regulation and RNA processing by the Integrator complex
K Sabath, S Jonas - Current Opinion in Structural Biology, 2022 - Elsevier
The metazoan-specific Integrator complex is a> 1.5 MDa machinery that interacts with RNA
polymerase II (RNAP2) to attenuate coding gene transcription by early termination close to …
polymerase II (RNAP2) to attenuate coding gene transcription by early termination close to …
MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1
A Downie Ruiz Velasco, AL Parsons… - Nucleic Acids …, 2024 - academic.oup.com
In animals, microRNA (miRNA) biogenesis begins with cotranscriptional cleavage of the
primary (pri-) miRNA by the Microprocessor complex. Cotranscriptional splicing has been …
primary (pri-) miRNA by the Microprocessor complex. Cotranscriptional splicing has been …
Structural basis of the Integrator complex assembly and association with transcription factors
M Razew, A Fraudeau, MM Pfleiderer, R Linares… - Molecular Cell, 2024 - cell.com
Integrator is a multi-subunit protein complex responsible for premature transcription
termination of coding and non-coding RNAs. This is achieved via two enzymatic activities …
termination of coding and non-coding RNAs. This is achieved via two enzymatic activities …
Neuronal differentiation requires BRAT1 complex to remove REST from chromatin
S Dokaneheifard… - Proceedings of the …, 2024 - National Acad Sciences
Repressor element-1 silencing transcription factor (REST) is required for the formation of
mature neurons. REST dysregulation underlies a key mechanism of neurodegeneration …
mature neurons. REST dysregulation underlies a key mechanism of neurodegeneration …
Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of
XPO1 inhibitors, selinexor and eltanexor, in high-risk myelodysplastic neoplasms (MDS) …
XPO1 inhibitors, selinexor and eltanexor, in high-risk myelodysplastic neoplasms (MDS) …
LncRNA 220: A Novel Long Non-Coding RNA Regulates Autophagy and Apoptosis in Kupffer Cells via the miR-5101/PI3K/AKT/mTOR Axis in LPS-Induced …
Y Yang, T Tian, S Li, N Li, H Luo, Y Jiang - International Journal of …, 2023 - mdpi.com
Sepsis is a severe medical condition distinguished by immune systematic dysfunction and
multiple organic injury, or even failure, resulting from an acute systemic inflammatory …
multiple organic injury, or even failure, resulting from an acute systemic inflammatory …
Tumour-regulatory role of long non-coding RNA HOXA-AS3
Dysregulation of long non-coding RNA (lncRNA) HOXA-AS3 has been shown to contribute
to the development of multiple cancer types. Several studies have presented the tumour …
to the development of multiple cancer types. Several studies have presented the tumour …