Cancer has become one of the greatest threats to human health, and new technologies are
urgently needed to further clarify the mechanisms of cancer so that better detection and …

The biological regulation of transcription factors (TFs) and repressor proteins is an important
mechanism for maintaining cell homeostasis. In B cell acute lymphoblastic leukemia (B-ALL) …

Mesenchymal stem cells (MSCs) are a common kind of multipotent cell in vivo, but their
heterogeneity limits their further applications. To identify MSC subpopulations and clarify …

Minimal residual disease that persists after chemotherapy is the most valuable prognostic
marker for haematological malignancies and solid cancers. Unfortunately, our …

The E26 transformation specific (ETS) family comprises 28 transcription factors, the majority
of which are involved in tumor initiation and development. Serving as a group of functionally …

Transcriptional profiling of acute leukemia, specifically by RNA-sequencing or whole
transcriptome sequencing (WTS), has provided fundamental insights into its underlying …

Childhood cancer is the second leading cause of death in children aged 1 to 14. Although
survival rates have vastly improved over the past 40 years, cancer resistance and relapse …

Simple Summary Although the prognosis of acute lymphoblastic leukemia (ALL) has
improved significantly during the past decades, ALL remains a major cause of pediatric …

Opinion statement Acute lymphoblastic leukemia (ALL) is the most frequent type of pediatric
cancer with a peak incidence at 2–5 years of age. ALL frequently begins in utero with the …

Despite recent progress in identifying the genetic drivers of acute lymphoblastic leukemia
(ALL), prognosis remains poor for those individuals who experience disease recurrence …