Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs

SA Dilliard, DJ Siegwart - Nature Reviews Materials, 2023 - nature.com
Genetic drugs based on nucleic acid biomolecules are a rapidly emerging class of
medicines that directly reprogramme the central dogma of biology to prevent and treat …

Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

W Chen, M Schilperoort, Y Cao, J Shi, I Tabas… - Nature Reviews …, 2022 - nature.com
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

The exit of nanoparticles from solid tumours

LNM Nguyen, ZP Lin, S Sindhwani, P MacMillan… - Nature Materials, 2023 - nature.com
Nanoparticles enter tumours through endothelial cells, gaps or other mechanisms, but how
they exit is unclear. The current paradigm states that collapsed tumour lymphatic vessels …

Understanding ligand-protected noble metal nanoclusters at work

MF Matus, H Häkkinen - Nature Reviews Materials, 2023 - nature.com
Ligand-protected noble metal nanoclusters, commonly termed 'monolayer-protected metal
clusters'(MPCs), comprise a common set of structures with an inorganic core stabilized by an …

On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles

SA Dilliard, Q Cheng… - Proceedings of the …, 2021 - National Acad Sciences
Lipid nanoparticles (LNPs) are a clinically mature technology for the delivery of genetic
medicines but have limited therapeutic applications due to liver accumulation. Recently, our …

Chemical and biophysical signatures of the protein corona in nanomedicine

J Ren, N Andrikopoulos, K Velonia… - Journal of the …, 2022 - ACS Publications
An inconvenient hurdle in the practice of nanomedicine is the protein corona, a spontaneous
collection of biomolecular species by nanoparticles in living systems. The protein corona is …

Protein nanoparticles in drug delivery: animal protein, plant proteins and protein cages, albumin nanoparticles

E Kianfar - Journal of Nanobiotechnology, 2021 - Springer
In this article, we will describe the properties of albumin and its biological functions, types of
sources that can be used to produce albumin nanoparticles, methods of producing albumin …

Anti-PEG antibodies boosted in humans by SARS-CoV-2 lipid nanoparticle mRNA vaccine

Y Ju, WS Lee, EH Pilkington, HG Kelly, S Li, KJ Selva… - Acs Nano, 2022 - ACS Publications
Humans commonly have low level antibodies to poly (ethylene) glycol (PEG) due to
environmental exposure. Lipid nanoparticle (LNP) mRNA vaccines for SARS-CoV-2 contain …

Environmental dimensions of the protein corona

KE Wheeler, AJ Chetwynd, KM Fahy, BS Hong… - Nature …, 2021 - nature.com
The adsorption of biomolecules to the surface of engineered nanomaterials, known as
corona formation, defines their biological identity by altering their surface properties and …

Nonspecific binding—fundamental concepts and consequences for biosensing applications

A Frutiger, A Tanno, S Hwu, RF Tiefenauer… - Chemical …, 2021 - ACS Publications
Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …