Abstract Acute Myeloid Leukaemia (AML) is a genetically, biologically and clinically
heterogeneous set of diseases, which are characterised by an increased growth of …

Abstract Interleukin-1β (IL-1β) is a pleiotropic cytokine that exerts multiple roles in both
physiological and pathological conditions. It is produced by different cell subsets, and drives …

Bone marrow mesenchymal stromal cells (MSCs) constitute one of the important
components of the hematopoietic microenvironmental niche. In vivo studies have shown that …

The contribution of molecular alterations in bone marrow mesenchymal stromal cells (BM-
MSC) to the pathogenesis of acute myeloid leukemia (AML) is poorly understood. Thus we …

The growth of malignant cells is not only driven by cell-intrinsic factors, but also by the
surrounding stroma. Monocytes/Macrophages play an important role in the onset and …

Leukemia is a cancer of the white blood cells, with over 54,000 new cases per year
diagnosed worldwide and a 5-year survival rate below 60%. This highlights a need for …

Introduction: Approximately 23% of acute myeloid leukemia (AML) patients younger than 60
years of age carry a mutation in the transmembrane domain of the FMS-like tyrosine kinase …

The role of proinflammatory cytokines secreted by the bone marrow mesenchymal stromal
cells (BM‐MSCs) in the progression of acute myeloid leukemia (AML) is poorly understood …

State of tumor microenvironment (TME) is closely linked to regulation of tumor growth and
progression affecting the final outcome, refractoriness, and relapse of disease. Interactions …

Abstract Background Ginsenoside Rg1 (Rg1) is one of the most active ingredients in Panax
ginseng and has been proven to have anti-oxidative and anti-aging properties. However …