DNA methylation in childhood asthma: an epigenome-wide meta-analysis
CJ Xu, C Söderhäll, M Bustamante, N Baïz… - The lancet Respiratory …, 2018 - thelancet.com
Background DNA methylation profiles associated with childhood asthma might provide
novel insights into disease pathogenesis. We did an epigenome-wide association study to …
novel insights into disease pathogenesis. We did an epigenome-wide association study to …
[HTML][HTML] Barrier impairment and type 2 inflammation in allergic diseases: the pediatric perspective
M Ghezzi, E Pozzi, L Abbattista, L Lonoce, GV Zuccotti… - Children, 2021 - mdpi.com
Allergic diseases represent a global burden. Although the patho-physiological mechanisms
are still poorly understood, epithelial barrier dysfunction and Th2 inflammatory response …
are still poorly understood, epithelial barrier dysfunction and Th2 inflammatory response …
[HTML][HTML] Microbiome research and multi-omics integration for personalized medicine in asthma
Asthma is a multifactorial inflammatory disorder of the respiratory system characterized by
high diversity in clinical manifestations, underlying pathological mechanisms and response …
high diversity in clinical manifestations, underlying pathological mechanisms and response …
[PDF][PDF] Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity
Asthma is a complex disease that varies widely in prevalence across populations. The
extent to which genetic variation contributes to these disparities is unclear, as the genetics …
extent to which genetic variation contributes to these disparities is unclear, as the genetics …
[HTML][HTML] Niosome nanocarrier enhances the ameliorating effects of myrtenol in the lungs of rats with experimental asthma
We assessed the anti-inflammatory, anti-oxidative and anti-remodeling impacts of a
synthesized myrtenol-loaded niosome in rats with allergic asthma. Forty-nine rats were …
synthesized myrtenol-loaded niosome in rats with allergic asthma. Forty-nine rats were …
Sex-and age-dependent DNA methylation at the 17q12-q21 locus associated with childhood asthma
Abstract Chromosomal region 17q12-q21 is one of the best-replicated genome-wide
association study (GWAS) hits and associated with childhood-onset asthma. However, the …
association study (GWAS) hits and associated with childhood-onset asthma. However, the …
[HTML][HTML] African ancestry is associated with asthma risk in African Americans
C Flores, SF Ma, M Pino-Yanes, MS Wade… - PloS one, 2012 - journals.plos.org
Background Asthma is a common complex condition with clear racial and ethnic differences
in both prevalence and severity. Asthma consultation rates, mortality, and severe symptoms …
in both prevalence and severity. Asthma consultation rates, mortality, and severe symptoms …
The Peru Urban versus Rural Asthma (PURA) Study: methods and baseline quality control data from a cross-sectional investigation into the prevalence, severity …
CL Robinson, LM Baumann, RH Gilman, K Romero… - BMJ open, 2012 - bmjopen.bmj.com
Objectives According to a large-scale international survey, Peru has one of the highest
prevalences of asthma worldwide; however, data from this survey were limited to …
prevalences of asthma worldwide; however, data from this survey were limited to …
[HTML][HTML] How the immune system responds to allergy immunotherapy
IgE-mediated diseases represent a highly diversified and multifactorial group of disorders
that can deeply impact the patients' quality of life. Currently, allergy immunotherapy (AIT) still …
that can deeply impact the patients' quality of life. Currently, allergy immunotherapy (AIT) still …
[HTML][HTML] Exploring TSLP and IL-33 Serum Levels and Genetic Variants: Unveiling Their Limited Potential as Biomarkers for Mild Asthma in Children
J Połomska, H Sikorska-Szaflik… - Journal of Clinical …, 2024 - mdpi.com
As the burden of mild asthma is not well understood, the significance of expanding research
in the group of patients with mild asthma is emphasized. Thymic stromal lymphopoietin …
in the group of patients with mild asthma is emphasized. Thymic stromal lymphopoietin …