Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

The modification of proteins with non‐protein entities is important for a wealth of
applications, and methods for chemically modifying proteins attract considerable attention …

Chemical modification of proteins is an important tool for probing natural systems, creating
therapeutic conjugates and generating novel protein constructs. Site-selective reactions …

Cys‐tematic modification: Cysteine is a versatile amino acid for selective chemical
modification of proteins. Both chemical and biological innovations made possible by …

Chemical modification of protein is an arduous but fruitful task. Many chemical methods
have been developed for such purpose by carefully balancing reactivity and selectivity. Now …

Hemoglobin (Hb) is a promiscuous protein that not only transports oxygen, but also
catalyzes several biotransformations. A novel in vitro catalytic activity of Hb is described …

Bioconjugation of nucleic acids with peptides, proteins, and other biomolecules is of
paramount importance in medicinal chemistry and chemical biology.[1] In most cases, the …

Herein, we report use of 2-azidoacrylates to perform site-specific dual functionalization of the
cysteine residue of peptides and bovine serum albumin (BSA), a native protein containing …

It has recently emerged that the succinimide linkage of a maleimide thiol addition product is
fragile, which is a major issue in fields where thiol functionalisation needs to be robust …

A core–shell ensemble of bovine hemoglobin (Hb) and human serum albumin (HSA) is an
artificial O2 carrier as a red blood cell substitute. This protein particle is created by covalent …