Schizophrenia is a heterogeneous psychiatric disorder, which can severely impact social
and professional functioning. Epidemiological and clinical studies show that schizophrenia …

The fetal origins of adult disease (FOAD) hypothesis, which was proposed by David Barker
in the United Kingdom in the late 1980s, posited that adult chronic diseases originated from …

Proper neuronal migration and laminar formation during corticogenesis is essential for
normal brain function. Disruption of these developmental processes is thought to be …

Risk for neuropsychiatric disorders is complex and includes an individual's internal genetic
endowment and their environmental experiences and exposures. Embryonic development …

REELIN (RELN) is a large (420 kDa) glycoprotein that in adulthood is mostly synthesized in
GABAergic neurons of corticolimbic structures. Upon secretion in the extracellular matrix …

Reelin is an extracellular matrix glycoprotein reduced in brain regions (the prefrontal cortex
and the hippocampus) of patients with schizophrenia. There are diverse rodent models of …

Genetic and environmental models of neuropsychiatric disease have grown exponentially
over the last 20 years. One measure that is often used to evaluate the translational …

The secreted glycoprotein Reelin is believed to play critical roles in the pathogenesis of
several neuropsychiatric disorders. The highly basic C-terminal region (CTR) of Reelin is …

Epidemiological studies show that social determinants of health are among the strongest
factors associated with developmental outcomes after prenatal and perinatal brain injuries …

Schizophrenia is a chronic severe mental disorder with a presumed neurodevelopmental
origin, and no effective treatment. Schizophrenia is a multifactorial disease with genetic …