The complement system plays a crucial role in the innate defense against common
pathogens. Activation of complement leads to robust and efficient proteolytic cascades …

The complement system of innate immunity is important in regulating humoral immunity
largely through the complement receptor CR2, which forms a coreceptor on B cells during …

Many nanoscale biomaterials fail to reach the clinical trial stage due to a poor understanding
of the fundamental principles of their in vivo behaviour. Here we describe the transport …

Protein–protein interactions (PPIs) play an important role in the different functions of cells,
but accurate prediction of the three-dimensional structures for PPIs is still a notoriously …

The complement system is a central component of innate immunity and bridges the innate to
the adaptive immune response. However, it can also turn its destructive capabilities against …

The mammalian complement system is a phylogenetically ancient cascade system that has
a major role in innate and adaptive immunity. Activation of component C3 (1,641 residues) is …

We characterize a novel hemocyte-specific acute phase glycoprotein from the malaria
vector, Anopheles gambiae. It shows substantial structural and functional similarities …

Resistance to infection and clearance of cell debris in mammals depend on the activation of
the complement system, which is an important component of innate and adaptive immunity …

Complement in mammalian plasma recognizes pathogenic, immunogenic and apoptotic cell
surfaces, promotes inflammatory responses and marks particles for cell lysis, phagocytosis …

Complement factor H (FH) attenuates C3b molecules tethered by their thioester domains to
self surfaces and thereby protects host tissues. Factor H is a cofactor for initial C3b …