Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

LD Nguyen, BE Ehrlich - EMBO molecular medicine, 2020 - embopress.org
Chemotherapy is a life‐saving treatment for cancer patients, but also causes long‐term
cognitive impairment, or “chemobrain”, in survivors. However, several challenges, including …

Microglia in cancer therapy-related cognitive impairment

EM Gibson, M Monje - Trends in neurosciences, 2021 - cell.com
Millions of cancer survivors experience a persistent neurological syndrome that includes
deficits in memory, attention, information processing, and mental health. Cancer therapy …

Doxorubicin-induced cognitive impairment: the mechanistic insights

J Du, A Zhang, J Li, X Liu, S Wu, B Wang… - Frontiers in …, 2021 - frontiersin.org
Chemotherapy can significantly prolong the survival of patients with breast cancer;
Nevertheless, the majority of patients receiving chemotherapy such as doxorubicin may …

Doxorubicin and cisplatin induced cognitive impairment: the possible mechanisms and interventions

B Ongnok, N Chattipakorn, SC Chattipakorn - Experimental neurology, 2020 - Elsevier
Chemotherapy has significantly increased the number of cancer survivors. However,
chemotherapy itself carries various adverse effects that limit the efficacy of treatment and …

Mechanisms of chemotherapy-induced neurotoxicity

H Was, A Borkowska, A Bagues, L Tu… - Frontiers in …, 2022 - frontiersin.org
Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been
extensively used in the clinic as the main cancer treatment either alone or as an adjuvant …

Animal models of chemotherapy-induced cognitive decline in preclinical drug development

J John, M Kinra, J Mudgal, GL Viswanatha… - …, 2021 - Springer
Rationale Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog
are the common terms for mental dysfunction in a cancer patient/survivor under the influence …

Chemobrain in breast cancer: mechanisms, clinical manifestations, and potential interventions

GR Onzi, N D'Agustini, SC Garcia, SS Guterres… - Drug safety, 2022 - Springer
Among the potential adverse effects of breast cancer treatment, chemotherapy-related
cognitive impairment (CRCI) has gained increased attention in the past years. In this review …

Doxorubicin-induced neurotoxicity is associated with acute alterations in synaptic plasticity, apoptosis, and lipid peroxidation

AH Alhowail, J Bloemer, M Majrashi… - Toxicology …, 2019 - Taylor & Francis
Cognitive deficits are commonly reported by patients following treatment with
chemotherapeutic agents. Anthracycline-containing chemotherapy regimens are associated …

[HTML][HTML] HDAC6 inhibition reverses long-term doxorubicin-induced cognitive dysfunction by restoring microglia homeostasis and synaptic integrity

BR McAlpin, R Mahalingam, AK Singh, S Dharmaraj… - Theranostics, 2022 - ncbi.nlm.nih.gov
Breast cancer is the most common female malignancy in both the developed and
developing world. Doxorubicin is one of the most commonly used chemotherapies for breast …

Experimental traumatic brain injury induces chronic glutamatergic dysfunction in amygdala circuitry known to regulate anxiety-like behavior

JA Beitchman, DR Griffiths, Y Hur, SB Ogle… - Frontiers in …, 2020 - frontiersin.org
Up to 50% of traumatic brain injury (TBI) survivors demonstrate persisting and late-onset
anxiety disorders indicative of limbic system dysregulation, yet the pathophysiology …