Despite their functional and structural diversity, G-protein-coupled receptors (GPCRs) share
a common mechanism of signal transduction via conformational changes in the seven …

The value of thoroughly understanding the thermodynamics specific to a drug
discovery/design study is well known. Over the past decade, the crucial roles of water …

Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …

G-protein-coupled receptors (GPCRs) are involved in numerous physiological processes
and are the most frequent targets of approved drugs. The explosion in the number of new …

Recent crystal structures of G-protein-coupled receptors (GPCRs) have revealed ordered
internal water molecules, raising questions about the functional role of those waters for …

Roughly half of the drug overdose-related deaths in the United States are related to
synthetic opioids represented by fentanyl which is a potent agonist of mu-opioid receptor …

G protein–coupled receptors (GPCRs) represent the largest family of cell membrane
proteins, with> 800 GPCRs in humans alone, and recognize highly diverse ligands, ranging …

The development of safe therapeutics to manage pain is of central interest for biomedical
applications. The fluorinated fentanyl derivative N-(3-fluoro-1-phenethylpiperidin-4-yl)-N …

Allosteric signaling in biological molecules, which may be viewed as specific action at a
distance due to localized perturbation upon binding of ligands or changes in environmental …

Many central biological events rely on protein–ligand interactions. The identification and
characterization of protein-binding sites for ligands are crucial for the understanding of …