Increasing interest in C (sp3)–H bond functionalization has led to a multitude of recent
advances in intramolecular C (sp3)–H amination. Direct, intramolecular C (sp3)–N bond …

In the present study a series of urea and sulfamide compounds incorporating the tetralin
scaffolds were synthesized and evaluated for their acetylcholinesterase (AChE), human …

Aryl and heteroaryl rings are omnipresent in small molecule drugs, and examples bearing
multiple substitutions at benzylic positions are ubiquitous across a range of pharmaceutical …

A one-pot reaction for the transformation of common secondary amides into amines with C–
C bond formation is described. This method consists of in situ amide activation with Tf2O …

Directed lithiation of substituted aromatics and heterocycles containing a directing
metalating group with alkyllithium in anhydrous tetrahydrofuran or diethyl ether at low …

The reduction of secondary amides to amines is an important transformation for the total
synthesis of alkaloids and pharmaceuticals. General and chemoselective direct methods for …

The spectroscopic properties of (E)-3-(4-bromo-5-methylthiophen-2-yl) acrylonitrile have
been investigated by FT-IR, UV, 1 H and 13 C NMR techniques. The theoretical vibrational …

Described in this paper are the results of an investigation on the extension of the C‐H
alkyliminylation and acylation of alkenes with secondary amides. The nucleophilic partner …

Amides are a class of highly stable carbonyl compounds, which are widely used as reliable
synthetic intermediates in both organic synthesis and pharmaceutical chemistry. Thus, the …

Lithiation of N-(pyridin-3-ylmethyl) pivalamide, tert-butyl N-(pyridin-3-ylmethyl) carbamate,
and N, N-dimethyl-N′-(pyridin-3-ylmethyl) urea with tert-butyllithium (3 equiv) in anhydrous …