Immunotherapy has made significant strides in cancer treatment, particularly through
immune checkpoint blockade (ICB), which has shown notable clinical benefits across …

T cells are an important component of adaptive immunity and protect the host from infectious
diseases and cancers. However, uncontrolled T cell immunity may cause autoimmune …

Hepatitis B virus (HBV)-specific CD8+ T cells play a dominant role during acute-resolving
HBV infection but are functionally impaired during chronic HBV infection in humans. These …

Adoptive cell therapy (ACT) using in vitro expanded tumor-infiltrating lymphocytes (TILs) has
inconsistent clinical responses. To better understand determinants of therapeutic success …

Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves
antitumor immune responses in preclinical studies, clinical success has been limited by on …

CD8+ T cells are the workhorses executing adaptive anti-tumour response, and targets of
various cancer immunotherapies. Latest advances have unearthed the sheer heterogeneity …

Summary Interleukin-2 (IL-2) is a critical cytokine for T cell peripheral tolerance and
immunity. Here, we review how IL-2 interaction with the high-affinity IL-2 receptor (IL-2R) …

A steady dysfunctional state caused by chronic antigen stimulation in the tumor
microenvironment (TME) is known as CD8+ T cell exhaustion. Exhausted-like CD8+ T cells …

Background: Glioblastoma (GBM) is characterized by abundant neovascularization as an
essential hallmark. Vasculogenic mimicry (VM) is a predominant pattern of GBM …

Abbreviations: ALD, alcohol-associated liver disease; CD, cluster of differentiation; CLD,
chronic liver disease; fGSEA, fast gene set enrichment analysis; HFHC, high-fat, high …