James Parkinson first described the motor symptoms of the disease that took his name over
200 years ago. While our knowledge of many of the changes that occur in this condition has …

Significance: The molecular machinery regulating autophagy has started becoming
elucidated, and a number of studies have undertaken the task to determine the role of …

Oxidative stress contributes to the cascade leading to dopamine cell degeneration in
Parkinson's disease (PD). However, oxidative stress is intimately linked to other components …

Parkinson's disease is one of the most common neurodegenerative diseases in the elderly.
The motor symptoms occur predominantly due to substantial dopamine depletion, caused by …

Chronic systemic complex I inhibition caused by rotenone exposure induces features of
Parkinson's disease (PD) in rats, including selective nigrostriatal dopaminergic …

Multiple genetic and environmental factors play a role in the development and progression
of Parkinson's disease (PD). The main neuropathological hallmark of PD is the degeneration …

Neurological disorders cause gastrointestinal (GI) symptoms that are debilitating and
markedly diminish quality of life in patients. The enteric nervous system (ENS), the intrinsic …

Paraquat, MPTP, and rotenone reproduce features of Parkinson's disease (PD) in
experimental animals. The exact mechanisms by which these compounds damage the …

Oxidative stress is a ubiquitously observed hallmark of neurodegenerative disorders.
Neuronal cell dysfunction and cell death due to oxidative stress may causally contribute to …

The molecular mechanisms mediating degeneration of midbrain dopamine neurons in
Parkinson's disease (PD) are poorly understood. Here, we provide evidence to support a …