Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
Synthesis, in vitro bio-evaluation, and molecular docking study of thiosemicarbazone-based isatin/bis-Schiff base hybrid analogues as effective cholinesterase …
Analogues of isatin/bis-Schiff bases based on thiocarbohydrazone (1–16) were synthesized,
characterised using various methods like NMR and HR-ESI-MS, and then tested against the …
characterised using various methods like NMR and HR-ESI-MS, and then tested against the …
Anti-Alzheimer's Studies on β-Sitosterol Isolated from Polygonum hydropiper L.
The family Polygonaceae is known for its traditional use in the management of various
neurological disorders including Alzheimer's disease (AD). In search of new anti-AD drugs …
neurological disorders including Alzheimer's disease (AD). In search of new anti-AD drugs …
Synthesis, in vitro α-amylase, α-glucosidase activities and molecular docking study of new benzimidazole bearing thiazolidinone derivatives
We have synthesized a series of benzimidazole bearing thiazolidinone derivatives (1-20),
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
Thiadiazole based triazole/hydrazone derivatives: Synthesis, in vitro α-glucosidase inhibitory activity and in silico molecular docking study
Thiadiazole-based hydrazide was treated with different substituted phenyl isothiocyanates
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
and benzaldehyde to synthesize thiadiazole-based triazole/hydrazone derivatives (4a–h & …
In vitro α-glucosidase and α-amylase inhibitory potential and molecular docking studies of benzohydrazide based imines and thiazolidine-4-one derivatives
Benzohydrazide based imine derivatives (1c-16c) and thiazolidine-4-one derivatives (1d-
16d) were synthesized and characterized with different spectroscopic techniques ie HREI …
16d) were synthesized and characterized with different spectroscopic techniques ie HREI …
The first synthesis of 4-phenylbutenone derivative bromophenols including natural products and their inhibition profiles for carbonic anhydrase, acetylcholinesterase …
The first synthesis of (E)-4-(3-bromo-4, 5-dihydroxyphenyl) but-3-en-2-one (1),(E)-4-(2-
bromo-4, 5-dihydroxyphenyl) but-3-en-2-one (2), and (E)-4-(2, 3-dibromo-4, 5 …
bromo-4, 5-dihydroxyphenyl) but-3-en-2-one (2), and (E)-4-(2, 3-dibromo-4, 5 …
Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling of
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
Discovery of novel coumarin-schiff base hybrids as potential acetylcholinesterase inhibitors: design, synthesis, enzyme inhibition, and computational studies
AH Hasan, FA Abdulrahman, AJ Obaidullah… - Pharmaceuticals, 2023 - mdpi.com
To discover anti-acetylcholinesterase agents for the treatment of Alzheimer's disease (AD), a
series of novel Schiff base-coumarin hybrids was rationally designed, synthesized …
series of novel Schiff base-coumarin hybrids was rationally designed, synthesized …
Synthesis of novel Schiff bases using green chemistry techniques; antimicrobial, antioxidant, antiurease activity screening and molecular docking studies
Schiff base derivatives were synthesized in this study via conventional, microwave
irradiation and ultrasound sonication methods. Optimization conditions were examined for …
irradiation and ultrasound sonication methods. Optimization conditions were examined for …