This review covers mainly the past 25 years of research on the biological activities of lupeol,
a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms …

Background Brazil has over 40,000 varied plant species rich in phytochemicals, expressing
20% of the world's flora. Due to its immense diversity, Brazil presents a high potential to …

Background Leishmaniasis comprises several infectious diseases caused by protozoa
parasites of Leishmania genus. In recent years, there has been a growing interest in the …

Stryphnodendron species, popularly named “barbatimão,” are traditionally used in Brazil as
anti‐inflammatory agents. This study aimed to investigate the effect of barbatimão and 11 …

Terpenoids are the largest and structurally most diverse group of secondary metabolites
derived from natural sources. Empirical evidence from several bioassays points to the …

Trypanothione reductase (TryR) is a key validated enzyme in the trypanothione‐based
redox metabolism of pathogenic trypanosomes and leishmania parasites. This system is …

Chagas disease is caused by Trypanosoma cruzi, being considered a public health
problem. An alternative to combat this pathogen is the use of natural products isolated from …

Glycosomes are peroxisome-related organelles found in all kinetoplastid protists, including
the human pathogenic species of the family Trypanosomatidae: Trypanosoma brucei …

Visceral Leishmaniasis (VL) has a high death rate, with 500,000 new cases and 50,000
deaths occurring annually. Despite the development of novel strategies and technologies …

Croton cajucara is a plant found in the Amazon region and is known for its medicinal
properties. The effects of the methanolic extract of the stem bark of C. cajucara (MCC) and of …