Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?
SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Atherosclerosis is the root cause of many cardiovascular diseases. Extensive research in
preclinical models and emerging evidence in humans have established the crucial roles of …
preclinical models and emerging evidence in humans have established the crucial roles of …
T cell subsets and functions in atherosclerosis
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …
Meta-analysis of leukocyte diversity in atherosclerotic mouse aortas
The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …
TREM2 macrophages induced by human lipids drive inflammation in acne lesions
Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves
excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes …
excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes …
Dendritic cell migration in health and disease
T Worbs, SI Hammerschmidt, R Förster - Nature Reviews Immunology, 2017 - nature.com
Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …
[HTML][HTML] GM-CSF in inflammation
JA Hamilton - Journal of Experimental Medicine, 2020 - rupress.org
Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions
than its original in vitro identification as an inducer of granulocyte and macrophage …
than its original in vitro identification as an inducer of granulocyte and macrophage …
New insights into the role of inflammation in the pathogenesis of atherosclerosis
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of
lipids, smooth muscle cell proliferation, cell apoptosis, necrosis, fibrosis, and local …
lipids, smooth muscle cell proliferation, cell apoptosis, necrosis, fibrosis, and local …
Inflammatory chemokines in atherosclerosis
Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the
formation of occlusive or rupture-prone lesions in large arteries. Complications of …
formation of occlusive or rupture-prone lesions in large arteries. Complications of …
[HTML][HTML] Biological drug and drug delivery-mediated immunotherapy
The initiation and development of major inflammatory diseases, ie, cancer, vascular
inflammation, and some autoimmune diseases are closely linked to the immune system …
inflammation, and some autoimmune diseases are closely linked to the immune system …