The immunogenicity of polysaccharides as human vaccines was enhanced by coupling to
protein carriers. Conjugation transformed the T cell-independent polysaccharide vaccines of …

Background Pneumonia, caused by Streptococcus pneumoniae, is a major cause of
morbidity and mortality among children in low‐income countries. The effectiveness of …

Background Changes in invasive pneumococcal disease (IPD) incidence were evaluated
after 7 years of 7-valent pneumococcal conjugate vaccine (PCV7) use in US children …

ContextA conjugate vaccine targeting 7 pneumococcal serotypes was licensed for young
children in 2000. In contrast to the 23-valent polysaccharide vaccine used in adults, the 7 …

Background When seven-valent pneumococcal conjugate vaccine was introduced in the
USA, many children were vaccinated on schedules that differed from those tested in clinical …

Objective: To describe NP and AOM otopathogens during the time frame 2007 to 2009, 6 to
8 years after the introduction of 7-valent pneumococcal conjugate (PCV7) in the United …

ContextChildren with cerebrospinal fluid (CSF) pleocytosis are routinely admitted to the
hospital and treated with parenteral antibiotics, although few have bacterial meningitis. We …

Background. Little is known about the epidemiology of invasive pneumococcal disease
(IPD) after the introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in Spain …

OBJECTIVES: The goals were to assess serial changes in Streptococcus pneumoniae
serotypes and antibiotic resistance in young children and to evaluate whether risk factors for …

Invasive infections caused by Streptococcus pneumoniae continue to be a major cause of
morbidity and mortality worldwide, especially in children under 5 years of age. In the United …