P-type ATPase are present in nearly all organisms. They maintain electrochemical gradients
for many solutes, in particular ions, they control membrane lipid asymmetry, and are crucial …

MFSD2A is a sodium-dependent lysophosphatidylcholine symporter that is responsible for
the uptake of docosahexaenoic acid into the brain,, which is crucial for the development and …

ATP11C, a plasma membrane phospholipid flippase, maintains the asymmetric distribution
of phosphatidylserine accumulated in the inner leaflet. Caspase-dependent inactivation of …

Eukaryotic plasma membranes (PMs) are energized by electrogenic P-type ATPases that
generate either Na+ or H+ motive forces to drive Na+ and H+ dependent transport …

ATP11C, a member of the P4-ATPase flippase, translocates phosphatidylserine from the
outer to the inner plasma membrane leaflet, and maintains the asymmetric distribution of …

Ion-transport mechanisms evolve by changing ion-selectivity, such as switching from Na+ to
H+ selectivity in secondary-active transporters or P-type-ATPases. Here we study primary …

The mammalian brain consists of 80% water, which is continuously shifted between different
compartments and cellular structures by mechanisms that are, to a large extent, unresolved …

Background Vonoprazan fumarate is a potassium-competitive acid blocker that was
developed as a novel acid-suppressing drug for multiple indications. As a potential …

As specific inhibitors of the gastric proton pump, responsible for gastric acidification, K+-
competitive acid blockers (P-CABs) have recently been utilized in the clinical treatment of …

ATP11C is a member of the P4-ATPase flippase family that mediates translocation of
phosphatidylserine (PtdSer) across the lipid bilayer. In order to characterize the structure …