Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signalling
pathways are affording demonstrable therapeutic efficacy in mouse models of cancer and in …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …

Gliomas are the most common primary brain tumors in adults. They arise in the glial tissue
and primarily occur in the brain. Low‐grade tumors of World Health Organization (WHO) …

Glioblastomas (GBMs), the most common primary brain tumor in adults, are characterized by
resistance to chemotherapy and radiotherapy. One of the defining characteristics of GBM is …

Glioblastomas, like other solid tumors, have extensive areas of hypoxia and necrosis. The
importance of hypoxia in driving tumor growth is receiving increased attention. Hypoxia …

Recent strategies for the treatment of cancer, other than just tumor cell killing have been
under intensive development, such as anti-angiogenic therapeutic approach. Angiogenesis …

Simple Summary The canonical WNT/β-catenin pathway is upregulated in cancers and
plays a major role in proliferation, invasion, apoptosis and angiogenesis. Recent studies …

Background Optimal extent of surgical resection (EOR) of high-grade gliomas (HGGs)
remains uncertain in the elderly given the unclear benefits and potentially higher rates of …

The Cancer Genome Atlas (TCGA) project has generated gene expression data that divides
glioblastoma (GBM) into four transcriptional classes: proneural, neural, classical, and …

The canonical Wnt/β-catenin pathway is up-regulated in gliomas and involved in
proliferation, invasion, apoptosis, vasculogenesis and angiogenesis. Nuclear β-catenin …