Pathogenesis and treatment of Sjogren's syndrome: review and update

Q Zhan, J Zhang, Y Lin, W Chen, X Fan… - Frontiers in …, 2023 - frontiersin.org
Sjogren's syndrome (SS) is a chronic autoimmune disease accompanied by multiple
lesions. The main manifestations include dryness of the mouth and eyes, along with …

Skin barrier dysregulation in psoriasis

A Orsmond, L Bereza-Malcolm, T Lynch… - International journal of …, 2021 - mdpi.com
The skin barrier is broadly composed of two elements—a physical barrier mostly localised in
the epidermis, and an immune barrier localised in both the dermis and epidermis. These two …

T peripheral helper cells in autoimmune diseases

KE Marks, DA Rao - Immunological reviews, 2022 - Wiley Online Library
Pathologic T cell–B cell interactions underlie many autoimmune diseases. The T cells that
help B cells in autoimmune diseases vary in phenotype and include T cells that lack typical …

The role of Th17 cells in psoriasis

B Li, L Huang, P Lv, X Li, G Liu, Y Chen, Z Wang… - Immunologic …, 2020 - Springer
Abstract T helper 17 (Th17) cells have been involved in the pathogenesis of many
autoimmune and inflammatory diseases, like psoriasis, multiple sclerosis (MS), rheumatoid …

The role of adipokines in the pathogenesis of psoriasis

K Kiełbowski, E Bakinowska, P Ostrowski… - International Journal of …, 2023 - mdpi.com
Psoriasis is a chronic and immune-mediated skin condition characterized by pro-
inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes …

Cytokines in psoriasis

CC de Alcantara, EMV Reiche, ANC Simão - Advances in clinical chemistry, 2021 - Elsevier
Psoriasis is chronic, immune-mediated, inflammatory disease with a multifactorial etiology
that affects the skin tissue and causes the appearance of dry and scaly lesions of anywhere …

Molecular control of pathogenic Th17 cells in autoimmune diseases

B Wu, Y Wan - International immunopharmacology, 2020 - Elsevier
Abstract IL-17A-producing CD4+ T helper cells (Th17) are crucial for the development of
inflammatory and autoimmune diseases and thus are exploited for clinical immunotherapies …

The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells

J Li, Z Xiao, D Wang, L Jia, S Nie, X Zeng, W Hu - Molecular Cancer, 2023 - Springer
Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

Interleukin‐21 in autoimmune and inflammatory skin diseases

A Mesas‐Fernández, E Bodner, FJ Hilke… - European Journal of …, 2023 - Wiley Online Library
Studies on the role of interleukins (ILs) in autoimmune and inflammatory diseases allow for
the better understanding of pathologic mechanisms of disease and reshaping of treatment …

[HTML][HTML] Tissue tregs and maintenance of tissue homeostasis

Q Shao, J Gu, J Zhou, Q Wang, X Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Regulatory T cells (Tregs) specifically expressing Forkhead box P3 (Foxp3) play roles in
suppressing the immune response and maintaining immune homeostasis. After maturation …