Pancreatic β-cells are finely tuned to secrete insulin so that plasma glucose levels are
maintained within a narrow physiological range (3.5-5.5 mmol/L). Hyperinsulinaemic …

Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the
unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic …

Genome-wide association studies have identified 240 independent loci associated with type
2 diabetes (T2D) risk, but this knowledge has not advanced precision medicine. In contrast …

Hypoglycemia is a heterogeneous disorder with many different possible etiologies, including
hyperinsulinism, glycogen storage disorders, fatty acid disorders, hormonal deficiencies …

Context Patients with congenital hyperinsulinism due to ABCC8 variants generally present
severe hypoglycemia and those who do not respond to medical treatment typically undergo …

Abstract Background Patients with Congenital Hyperinsulinism (CHI) due to mutations in K-
ATP channel genes (K-ATP CHI) are increasingly treated by conservative medical therapy …

Hyperinsulinaemic hypoglycaemia (HH) is a heterogeneous condition with dysregulated
insulin secretion which persists in the presence of low blood glucose levels. It is the most …

Regulation of pancreatic K ATP channels involves orchestrated interactions of their subunits,
Kir6. 2 and SUR1, and ligands. Previously we reported K ATP channel cryo-EM structures in …

Congenital Hyperinsulinism (CHI) is a rare disease of hypoglycaemia but is the most
common form of recurrent and severe hypoglycaemia causing brain injury and …

Congenital hyperinsulinism (CHI) is a clinically, genetically, and morphologically
heterogeneous disorder. 18 F DOPA-PET CT scanning greatly improves its clinical outcome …