Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Aging is a degenerative process associated with cumulative damage, which leads to cellular
dysfunction, tissue failure, and disorders of body function. Silent information regulator-1, also …

Exosomes are small membranous vesicles secreted by a number of cell types including
neurons and can be isolated from conditioned cell media or bodily fluids such as urine and …

MicroRNAs (miRNAs) are small non-coding RNA which have been shown to regulate gene
expression. The alteration ofmiRNAs expression has been associated with several …

Alzheimer's disease (AD) is a multifaceted, advancing neurodegenerative illness that is
responsible for most cases of neurological impairment and dementia in the aged population …

Abstract HUIBREGTSE, ME, Bazarian, JJ, Shultz, SR, and Kawata K. The biological
significance and clinical utility of emerging blood biomarkers for traumatic brain injury …

Drosophila melanogaster provides a powerful genetic model system in which to investigate
the molecular mechanisms underlying neurodegenerative diseases. In this review, we …

Background MicroRNAs (miRNAs) are endogenous small RNAs of 21–25 nucleotides that
post-transcriptionally regulate gene expressions. Recently, circulating miRNAs have been …