Opioids are the most commonly used and effective analgesic treatments for severe pain, but
they have recently come under scrutiny owing to epidemic levels of abuse and overdose …

Introduction: Opioids are the oldest and most potent drugs for the treatment of severe pain,
but they are burdened by detrimental side effects such as respiratory depression, addiction …

Morphine and fentanyl are among the most used opioid drugs that confer analgesia and
unwanted side effects through both G protein and arrestin signaling pathways of μ-opioid …

Opioids are effective analgesics, but their use is beset by serious side effects, including
addiction and respiratory depression, which contribute to the ongoing opioid crisis. The …

Background and Purpose PZM21 is a novel μ‐opioid receptor ligand that has been reported
to induce minimal arrestin recruitment and be devoid of the respiratory depressant effects …

Many central biological events rely on protein–ligand interactions. The identification and
characterization of protein-binding sites for ligands are crucial for the understanding of …

Mu-opioid agonists (eg, oxycodone) are highly effective therapeutics for pain. However, they
also produce reinforcing effects that increase their likelihood of abuse. Recent strategies in …

Pain is a complex multidimensional concept that facilitates the initiation of the signaling
cascade in response to any noxious stimuli. Action potential generation in the peripheral …

Aberrant expression, function, and mutation of G protein-coupled receptors (GPCRs) and
their signaling partners, G proteins, have been well documented in many forms of cancer …

Introduction: Pain relief remains a major public health challenge. The most efficient available
painkillers are opioids targeting the mu opioid receptor (MOR). MORs are expressed in the …