SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function
O Durydivka, K Mackie, J Blahos - Frontiers in Neuroscience, 2023 - frontiersin.org
In the central nervous system (CNS), cannabinoid receptor 1 (CB1R) is preferentially
expressed in axons where it has a unique property, namely resistance to agonist-driven …
expressed in axons where it has a unique property, namely resistance to agonist-driven …
The CB1 cannabinoid receptor regulates autophagy in the tibialis anterior skeletal muscle in mice
C Sepúlveda, JM Rodríguez, M Monsalves-Álvarez… - Biological Research, 2023 - Springer
The endocannabinoid system (ECS) regulates energy metabolism, has been implicated in
the pathogenesis of metabolic diseases and exerts its actions mainly through the type 1 …
the pathogenesis of metabolic diseases and exerts its actions mainly through the type 1 …
[HTML][HTML] Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling
ABSTRACT G protein-coupled receptors (GPCRs) exist within a landscape of
interconvertible conformational states and in dynamic equilibrium between monomers and …
interconvertible conformational states and in dynamic equilibrium between monomers and …
[PDF][PDF] 4.1. Case study 1. Discovery of homobivalent bitopic ligands of the cannabinoid CB2 receptor
Novel approaches to overcome the selectivity problem for the orthosteric binding site of
GPCRs include the discovery of bitopic ligands that bind the orthosteric site as well as a less …
GPCRs include the discovery of bitopic ligands that bind the orthosteric site as well as a less …
[引用][C] SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function
M Majellaro, M Vrecl, G Navarro, P Crepieux, J Blahos… - 2023 - europepmc.org
The Endocannabinoid System (ECS) is comprised of cannabinoid receptors, their
endogenous ligands, the endocannabinoids, and the enzymes that synthesize and degrade …
endogenous ligands, the endocannabinoids, and the enzymes that synthesize and degrade …