[HTML][HTML] Neurotheranostics as personalized medicines

BD Kevadiya, BM Ottemann, MB Thomas… - Advanced Drug Delivery …, 2019 - Elsevier
The discipline of neurotheranostics was forged to improve diagnostic and therapeutic
clinical outcomes for neurological disorders. Research was facilitated, in largest measure …

Nanotechnology in peripheral nerve repair and reconstruction

CR Carvalho, J Silva-Correia, JM Oliveira… - Advanced drug delivery …, 2019 - Elsevier
The recent progress in biomaterials science and development of tubular conduits (TCs) still
fails in solving the current challenges in the treatment of peripheral nerve injuries (PNIs), in …

Nanoscale effects in dendrimer-mediated targeting of neuroinflammation

E Nance, F Zhang, MK Mishra, Z Zhang… - Biomaterials, 2016 - Elsevier
Neuroinflammation, mediated by activated microglia and astrocytes, plays a key role in the
pathogenesis of many neurological disorders. Systemically-administered dendrimers target …

Targeting specific cells in the brain with nanomedicines for CNS therapies

F Zhang, YA Lin, S Kannan, RM Kannan - Journal of Controlled Release, 2016 - Elsevier
Abstract Treatment of Central Nervous System (CNS) disorders still remains a major clinical
challenge. The Blood–Brain Barrier (BBB), known as the major hindrance, greatly limits …

Anticancer copper (II) phosphorus dendrimers are potent proapoptotic Bax activators

S Mignani, N El Brahmi, L Eloy, J Poupon… - European Journal of …, 2017 - Elsevier
A multivalent phosphorus dendrimer 1G 3 and its corresponding Cu-complex, 1G 3-Cu have
been recently identified as agents retaining high antiproliferative potency. This …

Can dendrimer based nanoparticles fight neurodegenerative diseases? Current situation versus other established approaches

S Mignani, M Bryszewska, M Zablocka… - Progress in Polymer …, 2017 - Elsevier
For several decades, the treatment of central nervous system (CNS) disorders such as, for
instance, Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease …

In vivo therapeutic applications of phosphorus dendrimers: State of the art

S Mignani, X Shi, V Ceña, D Shcharbin… - Drug Discovery …, 2021 - Elsevier
Among the different types of dendrimers, those that incorporate phosphorus in various
positions in their structures present fascinating properties and have wide applications in …

The blood–brain barrier and beyond: Nano-based neuropharmacology and the role of extracellular matrix

P Henrich-Noack, D Nikitovic, M Neagu… - … , Biology and Medicine, 2019 - Elsevier
Restrained drug delivery due to the blood–brain barrier (BBB) considerably limits options for
the treatment of brain pathologies. The utilization of nanoparticulate (NP) carriers has been …

Treatment of refractory epilepsy patients with autologous mesenchymal stem cells reduces seizure frequency: an open label study

F Hlebokazov, T Dakukina, S Ihnatsenko… - Advances in medical …, 2017 - Elsevier
Purpose Existing anti-epileptic drugs (AED) have limited efficiency in many patients,
necessitating the search for alternative approaches such as stem cell therapy. We report the …

Dendrimers as powerful building blocks in central nervous system disease: headed for successful nanomedicine

V Leiro, S Duque Santos, CDF Lopes… - Advanced Functional …, 2018 - Wiley Online Library
Dendrimers have emerged as a powerful class of nanomaterials in the nanomedicine field
due to their unique structural features: globular, well‐defined, highly branched and …