Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

Microbes play an important role in aquatic carbon cycling but we have a limited
understanding of their functional responses to changes in temperature across large …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Several protein lysine methyltransferases and demethylases have been identified to have
critical roles in histone modification. A large body of evidence has indicated that their …

Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …

EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes
methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a …

Humans have adapted to the chronic hypoxia of high altitude in several locations, and
recent genome-wide studies have indicated a genetic basis. In some populations, genetic …

Protein lysine methylation is a distinct posttranslational modification that causes minimal
changes in the size and electrostatic status of lysine residues. Lysine methylation plays …