Biomarkers as prognostic predictors and therapeutic guide in critically ill patients: clinical evidence

R Méndez Hernández, F Ramasco Rueda - Journal of Personalized …, 2023 - mdpi.com
A biomarker is a molecule that can be measured in a biological sample in an objective,
systematic, and precise way, whose levels indicate whether a process is normal or …

Endotoxin in sepsis: methods for LPS detection and the use of omics techniques

GM Virzì, M Mattiotti, M de Cal, C Ronco, M Zanella… - Diagnostics, 2022 - mdpi.com
Lipopolysaccharide (LPS) or endotoxin, the major cell wall component of Gram-negative
bacteria, plays a pivotal role in the pathogenesis of sepsis. It is able to activate the host …

[HTML][HTML] Role of precision medicine and personalized medicine in the treatment of diseases

M Farrokhi, F Taheri, PJ Khouzani, E Rahmani… - Kindle, 2023 - preferpub.org
Precision medicine and personalized medicine are two approaches to healthcare that aim to
tailor medical treatments and interventions to individual patients. These approaches are …

Model-interpreted outcomes of artificial neural networks classifying immune biomarkers associated with severe infections in ICU

GS Martinez, AT Ostadgavahi, AM Al-Rafat… - Frontiers in …, 2023 - frontiersin.org
Introduction Millions of deaths worldwide are a result of sepsis (viral and bacterial) and
septic shock syndromes which originate from microbial infections and cause a dysregulated …

The critical role of neutrophil-endothelial cell interactions in sepsis: new synergistic approaches employing Organ-on-Chip, omics, immune cell phenotyping and in …

D Liu, JC Langston, B Prabhakarpandian… - Frontiers in Cellular …, 2024 - frontiersin.org
Sepsis is a global health concern accounting for more than 1 in 5 deaths worldwide. Sepsis
is now defined as life-threatening organ dysfunction caused by a dysregulated host …

Identifying biomarkers deciphering sepsis from trauma-induced sterile inflammation and trauma-induced sepsis

P Papareddy, M Selle, N Partouche, V Legros… - Frontiers in …, 2024 - frontiersin.org
Objective The purpose of this study was to identify a panel of biomarkers for distinguishing
early stage sepsis patients from non-infected trauma patients. Background Accurate …

Mechanism and therapeutic potential of traditional Chinese medicine extracts in sepsis

CF Fu, JL Li, JW Chen, H Liang, WR Zhao… - Frontiers in …, 2024 - frontiersin.org
Sepsis is a complex syndrome characterized by multi-organ dysfunction, due to the
presence of harmful microorganisms in blood which could cause mortality. Complications …

[HTML][HTML] Sepsis Biomarkers: Advancements and Clinical Applications—A Narrative Review

RR He, GL Yue, ML Dong, JQ Wang… - International Journal of …, 2024 - mdpi.com
Sepsis is now defined as a life-threatening syndrome of organ dysfunction triggered by a
dysregulated host response to infection, posing significant challenges in critical care. The …

Impact of high-density lipoproteins on sepsis

B De Geest, M Mishra - International journal of molecular sciences, 2022 - mdpi.com
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Here, we review the impact of high-density lipoproteins (HDL) on sepsis from the …

[HTML][HTML] Advancing temporal sepsis biomarking: Covariate vascular endothelial growth factor A and B gene expression profiling in a murine model of SARS-CoV …

A Rashid, F Al-Obeidat, K Ramakrishnan… - Informatics in Medicine …, 2024 - Elsevier
The limited specificity of standard inflammatory biomarkers poses a challenge for the
diagnosis and monitoring of sepsis. The differential gene expression patterns of Vascular …