Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids
Three-dimensional brain organoids have emerged as a valuable model system for studies of
human brain development and pathology. Here we establish a midbrain organoid culture …
human brain development and pathology. Here we establish a midbrain organoid culture …
Dopamine neuron diversity: Recent advances and current challenges in human stem cell models and single cell sequencing
Human midbrain dopamine (DA) neurons are a heterogeneous group of cells that share a
common neurotransmitter phenotype and are in close anatomical proximity but display …
common neurotransmitter phenotype and are in close anatomical proximity but display …
Silk scaffolding drives self-assembly of functional and mature human brain organoids
Human pluripotent stem cells (hPSCs) are intrinsically able to self-organize into cerebral
organoids that mimic features of developing human brain tissue. These three-dimensional …
organoids that mimic features of developing human brain tissue. These three-dimensional …
Generation of human ventral midbrain organoids derived from pluripotent stem cells
Parkinson's disease (PD) is the second most common neurodegenerative disorder
worldwide and is caused by the degeneration and loss of dopamine (DA) neurons in the …
worldwide and is caused by the degeneration and loss of dopamine (DA) neurons in the …
Advancements in Single-Cell RNA Sequencing Research for Neurological Diseases
B Yang, S Hu, Y Jiang, L Xu, S Shu, H Zhang - Molecular Neurobiology, 2024 - Springer
Neurological diseases are a major cause of the global burden of disease. Although the
mechanisms of the occurrence and development of neurological diseases are not fully clear …
mechanisms of the occurrence and development of neurological diseases are not fully clear …
Lineage tracing of stem cell–derived dopamine grafts in a Parkinson's model reveals shared origin of all graft-derived cells
Stem cell therapies for Parkinson's disease are at an exciting time of development, and
several clinical trials have recently been initiated. Human pluripotent stem cells are …
several clinical trials have recently been initiated. Human pluripotent stem cells are …
Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs
L Liang, Y Tian, L Feng, C Wang, G Feng… - Stem Cell Research & …, 2022 - Springer
Background Midbrain dopaminergic (DA) progenitors derived from human pluripotent stem
cells are considered to be a promising treatment for Parkinson's disease (PD). However, the …
cells are considered to be a promising treatment for Parkinson's disease (PD). However, the …
Long non-coding RNA (LncRNA) CASC9/microRNA (miR)-590–3p/sine oculis homeobox 1 (SIX1)/NF-κB axis promotes proliferation and migration in breast cancer
J Chang, Y Zhang, X Ye, H Guo, K Lu, Q Liu… - …, 2021 - Taylor & Francis
Long non-coding RNA (lncRNA)–microRNA–mRNA signaling axes have recently been
shown to have a key role in the development of breast cancer (BC). In this study, we …
shown to have a key role in the development of breast cancer (BC). In this study, we …
Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification
The Wnt/β-catenin signaling governs anterior-posterior neural patterning during
development. Current human pluripotent stem cell (hPSC) differentiation protocols use a …
development. Current human pluripotent stem cell (hPSC) differentiation protocols use a …
单细胞转录组测序技术在帕金森病中的应用
刘子瑜， 耿丹丹， 张润姣， 刘清， 李一博， 王宏方… - 中国组织工程研究, 2025 - cjter.com
单细胞转录组测序技术在帕金森病中的应用 Page 1 Chinese Journal of Tissue Engineering
Research|Vol 29|No.1|January 2025|193 中国组织工程研究 Chinese Journal of Tissue …
Research|Vol 29|No.1|January 2025|193 中国组织工程研究 Chinese Journal of Tissue …