Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Patients with diabetes mellitus have> 2× the risk for developing heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …

Heart failure (HF) has become increasingly common within the elderly population,
decreasing their survival and overall quality of life. In fact, despite the improvements in …

Left ventricular hypertrophy is a leading risk factor for cardiovascular morbidity and mortality.
Although reverse ventricular remodelling was long thought to be irreversible, evidence from …

Diet-induced obesity is a major risk factor for metabolic syndrome, diabetes and
cardiovascular disease. Here, we show that a 5-d fasting-mimicking diet (FMD) …

The mechanisms responsible for the positive and unexpected cardiovascular effects of
sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists in …

With research progress on longevity, we have gradually recognized that cardiac aging
causes changes in heart structure and function, including progressive myocardial …

As a muscular pump that contracts incessantly throughout life, the heart must constantly
generate cellular energy to support contractile function and fuel ionic pumps to maintain …

Abstract Purpose of Review To discuss the impact of deleterious changes in skeletal muscle
morphology and function on exercise intolerance in patients with heart failure with reduced …

Transfer RNAs (tRNAs) are abundantly expressed, small non-coding RNAs that have long
been recognized as essential components of the protein translation machinery. The tRNA …