Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …

Signalling pathways involving the vital second messanger, cAMP, impact on most significant
physiological processes. Unsurprisingly therefore, the activation and regulation of cAMP …

Many bacteria use extracellular signaling molecules to coordinate group behavior, a
process referred to as quorum sensing (QS). However, some QS molecules are hydrophobic …

The adenylyl cyclases (ACs) catalyze the production of the ubiquitous second messenger,
cAMP, which in turns acts on a number of effectors and thus regulates a plethora of cellular …

Class III adenylate cyclases (ACs) are widespread signaling proteins, which translate
diverse intracellular and extracellular stimuli into a uniform intracellular signal. They are …

Mycobacterium tuberculosis (Mtb) replicates within host macrophages by adapting to the
stressful and nutritionally constrained environments in these cells. Exploiting these …

There is a growing appreciation for the idea that bacterial utilization of host-derived lipids,
including cholesterol, supports Mycobacterium tuberculosis (Mtb) pathogenesis. This has …

Nucleotidyl cyclases, including membrane-integral and soluble adenylyl and guanylyl
cyclases, are central components in a wide range of signaling pathways. These proteins are …

The formation of biofilm by pathogenic bacteria is considered as one of the most powerful
mechanisms/modes of resistance against the action of several antibiotics. Biofilm is formed …

Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor
of the mammalian membrane ACs and a model system for studies of their structure and …