Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as
frequent in patients with diabetes compared with those who do not have diabetes. Moreover …

Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to
the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular …

The endothelium, which forms the inner cellular lining of blood vessels and lymphatics, is a
highly metabolically active organ that is involved in many physiopathological processes …

Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in
the consequences of both conditions and the mechanisms of action are poorly defined. Here …

Microvascular dysfunction (MVD) is considered a crucial pathway in the development and
progression of cardiometabolic and renal disease and is associated with increased …

Throughout the 20th and 21st centuries, the incidence of non-communicable diseases
(NCDs), also known as chronic diseases, has been increasing worldwide. Changes in …

Endothelial dysfunction associated with diabetes and cardiovascular disease is
characterized by changes in vasoregulation, enhanced generation of reactive oxygen …

New findings• What is the topic of this review? This review presents the paradigm shift in our
understanding of capillary structure and function that has occurred since 1920 (August …

OBJECTIVE Insulin increases glucose disposal in part by enhancing microvascular blood
flow (MBF) and substrate delivery to myocytes. Insulin's microvascular action is impaired …

Endothelium, acting as a barrier, protects tissues against factors that provoke insulin
resistance and type 2 diabetes and itself responds to the insult of insulin resistance inducers …