Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …

Amyotrophic lateral sclerosis (ALS) is a genetically diverse disease. At least 15 ALS-
associated gene loci have so far been identified, and the causative gene is known in …

Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

Several neurodegenerative disorders involve impaired neurotransmission, and
glutamatergic neurotransmission sets a prototypical example. Glutamate is a predominant …

Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results
in motor dysfunction and death, generally from respiratory failure. 90% of ALS cases are …

Mitochondria are regarded as the metabolic centers of cells and are integral in many other
cell processes, including the immune response. Each mitochondrion contains numerous …

Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disorder that is
characterized by the selective death of motor neurons. While the fundamental cause of the …

Despite some advances in the understanding of amyotrophic lateral sclerosis (ALS)
pathogenesis, significant achievements in treating this disease are still lacking …

Dysregulation of calcium homeostasis has been linked to multiple neurological diseases. In
addition to excitotoxic neuronal cell death observed following stroke, a growing number of …

Stress and glucocorticoids alter glutamatergic transmission, and the outcome of stress may
range from plasticity enhancing effects to noxious, maladaptive changes. We have …