Sequencing quality assessment tools to enable data-driven informatics for high throughput genomics
The processes of quality assessment and control are an active area of research at The
Genome Analysis Centre (TGAC). Unlike other sequencing centers that often concentrate on …
Genome Analysis Centre (TGAC). Unlike other sequencing centers that often concentrate on …
Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule …
A major challenge in cancer treatment is predicting the clinical response to anti-cancer
drugs on a personalized basis. The success of such a task largely depends on the ability to …
drugs on a personalized basis. The success of such a task largely depends on the ability to …
Qualimap 2: advanced multi-sample quality control for high-throughput sequencing data
Motivation: Detection of random errors and systematic biases is a crucial step of a robust
pipeline for processing high-throughput sequencing (HTS) data. Bioinformatics software …
pipeline for processing high-throughput sequencing (HTS) data. Bioinformatics software …
Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing
The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint
effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could …
effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could …
The gut microbiome of Mexican children affected by obesity
Obesity is a metabolic disorder and global health issue. In Mexico 34.4% of children
between 5 and 11 years-old are overweight or obese. Here we address this issue studying …
between 5 and 11 years-old are overweight or obese. Here we address this issue studying …
GacA is essential for Group A Streptococcus and defines a new class of monomeric dTDP‐4‐dehydrorhamnose reductases (RmlD)
SL van der Beek, Y Le Breton… - Molecular …, 2015 - Wiley Online Library
The sugar nucleotide d TDP‐L‐rhamnose is critical for the biosynthesis of the G roup A
Carbohydrate, the molecular signature and virulence determinant of the human pathogen G …
Carbohydrate, the molecular signature and virulence determinant of the human pathogen G …
[HTML][HTML] RNA-Seq: a glance at technologies and methodologies
SM Jazayeri, LM Melgarejo Munoz… - Acta Biológica …, 2015 - scielo.org.co
RNA Sequencing (RNA-Seq) is a newly born tool that has revolutionized the post-genomic
era. The data produced by RNA-Seq, sequencing technologies and use of bioinformatics …
era. The data produced by RNA-Seq, sequencing technologies and use of bioinformatics …
Music of metagenomics—A review of its applications, analysis pipeline, and associated tools
This humble effort highlights the intricate details of metagenomics in a simple, poetic, and
rhythmic way. The paper enforces the significance of the research area, provides details …
rhythmic way. The paper enforces the significance of the research area, provides details …
A multistate toggle switch defines fungal cell fates and is regulated by synergistic genetic cues
Heritable epigenetic changes underlie the ability of cells to differentiate into distinct cell
types. Here, we demonstrate that the fungal pathogen Candida tropicalis exhibits …
types. Here, we demonstrate that the fungal pathogen Candida tropicalis exhibits …
Next-Generation Sequencing Techniques Reveal that Genomic Imprinting Is Absent in Day-Old Gallus gallus domesticus Brains
Q Wang, K Li, D Zhang, J Li, G Xu, J Zheng, N Yang… - PLoS …, 2015 - journals.plos.org
Genomic imprinting is a phenomenon characterized by parent-of-origin-specific gene
expression. While widely documented in viviparous mammals and plants, imprinting in …
expression. While widely documented in viviparous mammals and plants, imprinting in …