Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

Mechanisms of multidrug resistance in cancer chemotherapy

K Bukowski, M Kciuk, R Kontek - International journal of molecular …, 2020 - mdpi.com
Cancer is one of the main causes of death worldwide. Despite the significant development of
methods of cancer healing during the past decades, chemotherapy still remains the main …

The role of polyphenols in overcoming cancer drug resistance: A comprehensive review

P Maleki Dana, F Sadoughi, Z Asemi… - Cellular & molecular …, 2022 - Springer
Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery.
However, cancers often develop resistance against drugs, leading to failure of treatment and …

Differentiated Caco-2 cell models in food-intestine interaction study: Current applications and future trends

X Ding, X Hu, Y Chen, J Xie, M Ying, Y Wang… - Trends in Food Science & …, 2021 - Elsevier
Background Food-intestine interaction study has always been a hot topic in food science
and nutrition due to diverse physiological functions of intestine. Compared to expensive …

Recent updates on mechanisms of resistance to 5-fluorouracil and reversal strategies in colon cancer treatment

S Azwar, HF Seow, M Abdullah, M Faisal Jabar… - Biology, 2021 - mdpi.com
Simple Summary Acquired resistance to chemotherapy by cancer cells is the predominant
factor in chemotherapy failure, which ultimately leads to disease progression and death …

Understanding and targeting resistance mechanisms in cancer

ZN Lei, Q Tian, QX Teng, JND Wurpel, L Zeng… - MedComm, 2023 - Wiley Online Library
Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

New advances in the research of resistance to neoadjuvant chemotherapy in breast cancer

J An, C Peng, H Tang, X Liu, F Peng - International journal of molecular …, 2021 - mdpi.com
Breast cancer has an extremely high incidence in women, and its morbidity and mortality
rank first among female tumors. With the increasing development of medicine today, the …

Glutathione transferases: potential targets to overcome chemoresistance in solid tumors

M Pljesa-Ercegovac, A Savic-Radojevic… - International journal of …, 2018 - mdpi.com
Multifunctional enzymes glutathione transferases (GSTs) are involved in the development of
chemoresistance, thus representing a promising target for a novel approach in cancer …

Drug-metabolizing enzymes: role in drug resistance in cancer

G Kaur, SK Gupta, P Singh, V Ali, V Kumar… - Clinical and Translational …, 2020 - Springer
Although continuous researches are going on for the discovery of new chemotherapeutic
agents, resistance to these anticancer agents has made it really difficult to reach the fruitful …

Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy

S Sur, RB Ray - Cancers, 2020 - mdpi.com
Cancer is the second leading cause of death worldwide. Many dietary plant products show
promising anticancer effects. Bitter melon or bitter gourd (Momordica charantia) is a nutrient …