Snake antivenom: Challenges and alternate approaches

A Alangode, K Rajan, BG Nair - Biochemical Pharmacology, 2020 - Elsevier
Snake envenomation is still a serious threat to many countries in the world. The only
mainstay treatment depends on the administration of animal derived immunoglobulin based …

Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations

AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …

Kaempferol from Moringa oleifera demonstrated potent antivenom activities via inhibition of metalloproteinase and attenuation of Bitis arietans venom–induced …

BS Ajisebiola, JO Oladele, AO Adeyi - Toxicon, 2023 - Elsevier
Bitis arietans venom (BAV) can induce severe pathophysiological disorders after
envenoming. However, studies have shown that the Moringa oleifera fraction is effective …

Naja naja snake venom-induced local toxicities in mice is by inflammasome activation

MB Nandana, M Bharatha, BS Vishwanath, R Rajaiah - Toxicon, 2024 - Elsevier
Snake bite envenomation causes tissue damage resulting in acute and chronic inflammatory
responses. Inflammasome activation is one of the factors involved in tissue damage in a …

Phytochemical characterization and phospholipase A2 inhibitory effect of Vitex negundo L. root extracts

S Kusar, Z Saddiqe, MHHB Asad, F Ali… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Snake bites are a critical health issue in many parts of the
world particularly in Asian countries lacking efficient health facilities in rural areas. Cobra is …

Revolutionizing snakebite care with novel antivenoms: Breakthroughs and barriers

SO Uko, I Malami, KG Ibrahim, N Lawal, MB Bello… - Heliyon, 2024 - cell.com
Snakebite envenoming (SBE) is a global public health concern, primarily due to the lack of
effective antivenom for treating snakebites inflicted by medically significant venomous …

Unraveling snake venom phospholipase A2: an overview of its structure, pharmacology, and inhibitors

GH Sampat, K Hiremath, J Dodakallanavar… - Pharmacological …, 2023 - Springer
Snake bite is a neglected disease that affects millions of people worldwide. WHO reported
approximately 5 million people are bitten by various species of snakes each year, resulting …

Assessment of snakebite burdens, clinical features of envenomation, and strategies to improve snakebite management in Vietnam

A Patra, AK Mukherjee - Acta tropica, 2021 - Elsevier
The sheer paucity of scientific documentation of herpetofauna in Vietnam and the
rudimentary healthcare response to snakebite have stimulated this review. Over six decades …

Exploring the inhibitory potential of phytochemicals from Vernonia glaberrima leaves against snake venom toxins through computational simulation and experimental …

AJ Yusuf, AI Bugaje, M Sadiq, M Salihu, HW Adamu… - Toxicon, 2024 - Elsevier
Abstract Phospholipase A 2 (PLA 2) is an enzyme present in appreciable quantity in snake
venoms which catalyze the hydrolysis of glycerophospholipids at sn-2 position and promote …

A First Look at the Inhibitory Potential of Urospatha sagittifolia (Araceae) Ethanolic Extract for Bothrops atrox Snakebite Envenomation

AL Vera-Palacios, JD Sacoto-Torres… - Toxins, 2022 - mdpi.com
Bothrops atrox snakebites are a relevant problem in the Amazon basin. In this biodiverse
region, the ethnomedicinal approach plays an important role as an alternative to antivenom …