Neuronal XBP-1 activates intestinal lysosomes to improve proteostasis in C. elegans

S Imanikia, NP Özbey, C Krueger, MO Casanueva… - Current Biology, 2019 - cell.com
The unfolded protein response of the endoplasmic reticulum (UPR ER) is a crucial mediator
of secretory pathway homeostasis. Expression of the spliced and active form of the UPR ER …

Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways

N Grahl, EG Demers, AK Lindsay, CE Harty… - PLoS …, 2015 - journals.plos.org
Candida albicans is both a major fungal pathogen and a member of the commensal human
microflora. The morphological switch from yeast to hyphal growth is associated with disease …

Inhibition of host PARP1 contributes to the anti-inflammatory and antitubercular activity of pyrazinamide

S Krug, M Gupta, P Kumar, L Feller, EA Ihms… - Nature …, 2023 - nature.com
The antibiotic pyrazinamide (PZA) is a cornerstone of tuberculosis (TB) therapy that shortens
treatment durations by several months despite being only weakly bactericidal. Intriguingly …

Enhanced mitochondrial membrane potential and ATP synthesis by photobiomodulation increases viability of the auditory cell line after gentamicin-induced intrinsic …

SY Chang, MY Lee, PS Chung, S Kim, B Choi… - Scientific reports, 2019 - nature.com
Photobiomodulation (PBM) has been suggested to have a therapeutic effect on irreversible
hearing loss induced by aminoglycosides, including gentamicin (GM). However, its …

Fed-batch mixotrophic cultivation of Chlamydomonas reinhardtii for high-density cultures

FJ Fields, JT Ostrand, SP Mayfield - Algal Research, 2018 - Elsevier
The green algae Chlamydomonas reinhardtii is a model organism that has been proposed
as a potential production platform for high-value recombinant products, but to date, there has …

Delineation of cell death mechanisms induced by synergistic effects of statins and erlotinib in non-small cell lung cancer cell (NSCLC) lines

A Otahal, D Aydemir, E Tomasich, C Minichsdorfer - Scientific Reports, 2020 - nature.com
Abstract Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have
been shown to overcome tyrosine kinase inhibitor (TKI) resistance in epithelial growth factor …

Dispersive liquid-liquid microextraction coupled with digital image colorimetric analysis for detection of total iron in water and food samples

B Peng, G Chen, K Li, M Zhou, J Zhang, S Zhao - Food chemistry, 2017 - Elsevier
A simple and low cost assay for total iron in various samples based on dispersive liquid-
liquid microextraction (DLLME) coupled with digital scanning image analysis was proposed …

Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity

S Seitz, Y Kwon, G Hartleben, J Jülg, R Sekar… - Nature …, 2019 - nature.com
Non-alcoholic fatty liver disease (NAFLD) represents a key feature of obesity-related type 2
diabetes with increasing prevalence worldwide. To our knowledge, no treatment options are …

Constituents of neutrophil extracellular traps induce in vitro collagen formation in mare endometrium

MR Rebordão, A Amaral, K Lukasik… - Theriogenology, 2018 - Elsevier
Neutrophil extracellular traps (NETs) are DNA complexes carrying nuclear and cytoplasmic
proteins, such as elastase (ELA), cathepsin-G (CAT) and myeloperoxidase (MPO). Mare …

Metabolic profiling and flux analysis of MEL-2 human embryonic stem cells during exponential growth at physiological and atmospheric oxygen concentrations

J Turner, LE Quek, D Titmarsh, JO Krömer, LP Kao… - PLoS …, 2014 - journals.plos.org
As human embryonic stem cells (hESCs) steadily progress towards regenerative medicine
applications there is an increasing emphasis on the development of bioreactor platforms that …