Ageing leads to profound alterations in the immune system and increases susceptibility to
some chronic, infectious and autoimmune diseases. In recent years, widespread application …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse
is a good model system for a young human, and an old mouse, for an elderly human. By …

The effects of aging on the immune system are widespread and extend from hematopoietic
stem cells and lymphoid progenitors in the bone marrow and thymus to mature lymphocytes …

Changes in T lymphocyte populations underlie much of the age-related decline in the
protective immune response. Aging leads to the replacement of virgin T cells by memory T …

Publisher Summary This chapter focuses on CD44 and its interaction with extracellular
matrix. CD44 is a broadly distributed family of cell surface glycoprotein that has been studied …

In this report, we have addressed two questions concerning immunological memory: the way
in which naive and memory T cells recirculate through the body, and the intrinsic rate of …

A diverse T cell repertoire is essential for a vigorous immune response to new infections,
and decreasing repertoire diversity has been implicated in the age-associated decline in …

Aging affects all tissues and organs. Aging of the immune system results in the severe
disruption of its functions, leading to an increased susceptibility to infections, an increase in …

On the basis of their surface markers, T lymphocytes are divided into subsets of" naive" and"
memory cells". We have defined the interrelationship and relative life spans of naive and …