At the cellular level, the biological processes of cell proliferation, growth arrest,
differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic …

The role of the Wnt signaling pathway in metabolic homeostasis has drawn our intensive
attention, especially after the genome-wide association study discovery that certain …

Type 2 diabetes mellitus (T2DM) is one of the major chronic diseases, whose prevalence is
increasing dramatically worldwide and can lead to a range of serious complications. Wnt …

No longer considered to be exclusive to cellular developmental pathways, the Wnt family of
secreted cysteine-rich glycosylated proteins has emerged as versatile targets for a variety of …

Preadipocytes secrete several WNT family proteins that act through autocrine/paracrine
mechanisms to inhibit adipogenesis. The activity of WNT ligands is often decreased by …

Several major developments have occurred since the last edition of Handbook of Obesity:
Clinical Applications, including new clinical trials, discoveries related to drug use, and …

Aims/hypothesis The wingless-type MMTV integration site (WNT) pathway mediates multiple
physiological and pathological processes, such as inflammation, angiogenesis and fibrosis …

Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment
of cell fates and proper tissue patterning during embryo development and for the regulation …

Objectives Bone remodelling is necessary to repair old and impaired bone caused by aging
and its effects. Injury in the process of bone remodelling generally leads to the development …

Osteoporosis, a chronic complication of diabetes mellitus, is characterized by a reduction in
bone mass, destruction of bone microarchitecture, decreased bone strength, and increased …