Parkinson's disease (PD), a neurodegenerative disorder characterized by distinct aging-
independent loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) region …

Cellular deposition of protein aggregates, one of the hallmarks of neurodegeneration,
disrupts cellular functions and leads to neuronal death. Mutations, posttranslational …

Alpha-synuclein (αSyn) protein levels correlate with the risk and severity of Parkinson's
disease and related neurodegenerative diseases. Lowering αSyn is being actively …

Mutations in the SNCA gene, which encodes the protein α-synuclein, have been linked with
early onset Parkinson's disease. The exact nature of this association, however, is still poorly …

Acetylation is a key post-translational modification (PTM) involved in the regulation of both
histone and non-histone proteins. It controls cellular processes such as DNA transcription …

Approximately 40% of the mammalian proteome undergoes N-terminal methionine excision
and acetylation, mediated sequentially by methionine aminopeptidase (MetAP) and N …

Accumulation of the neuronal presynaptic protein alpha-synuclein within proteinaceous
inclusions represents the key histophathological hallmark of a spectrum of …

Background and Purpose The integrated stress response (ISR) regulates translation in
response to diverse stresses. ISR activation has been documented in amyotrophic lateral …

α-Synuclein (α-syn), a small highly conserved presynaptic protein containing 140 amino
acids, is thought to be the main pathological hallmark in related neurodegenerative …

Parkinson's disease (PD) is a threatening neurodegenerative disorder that seriously affects
patients' life quality. Substantial evidence links the overexpression and abnormal …