Antibiotic resistance remains a significant threat to modern medicine. Modification of the
antibiotic target is a resistance strategy that is increasingly prevalent among pathogens …

Genome sequencing of Streptomyces, myxobacteria, and fungi showed that although each
strain contains genes that encode the enzymes to synthesize a plethora of potential …

Using cryo-electron microscopy (cryo-EM), we determined the structure of the Escherichia
coli 70S ribosome with a global resolution of 2.0 Å. The maps reveal unambiguous …

As bacteria and fungi have been found to contain genes encoding enzymes that synthesize
a plethora of potential secondary metabolites, interest has grown in the activation of these …

Prototypic Staphylococcus aureus and their small-colony variants (SCVs) are predominant
in cystic fibrosis (CF), but the interdependence of these phenotypes is poorly understood …

Although antimicrobial resistance genes (ARGs) in dozens of environments have been well
documented, the distribution of ARGs in salt lake ecosystems has been less intensively …

Post-translational methylation of rRNA at select positions is a prevalent resistance
mechanism adopted by pathogens. In this work, KsgA, a housekeeping ribosomal …

Objectives To elucidate the potential mutation-driven mechanisms involved in the
acquisition of tigecycline resistance by the opportunistic pathogen Stenotrophomonas …

Kasugamycin (KSM), a unique aminoglycoside antibiotic, has been used in agriculture for
many years to control not only rice blast caused by the fungus Magnaporthe grisea but also …

The recent findings that the narrow-specificity endoribonuclease RNase III and the 5′
exonuclease RNase J1 are not essential in the Gram-positive model organism, Bacillus …