Aging and DNA methylation
M Jung, GP Pfeifer - BMC biology, 2015 - Springer
In this Opinion article, we summarize how changes in DNA methylation occur during aging
in mammals and discuss examples of how such events may contribute to the aging process …
in mammals and discuss examples of how such events may contribute to the aging process …
Epigenetics and the biological definition of gene× environment interactions
MJ Meaney - Child development, 2010 - Wiley Online Library
Variations in phenotype reflect the influence of environmental conditions during
development on cellular functions, including that of the genome. The recent integration of …
development on cellular functions, including that of the genome. The recent integration of …
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.
JG Herman, JR Graff, S Myöhänen… - Proceedings of the …, 1996 - National Acad Sciences
Precise mapping of DNA methylation patterns in CpG islands has become essential for
understanding diverse biological processes such as the regulation of imprinted genes, X …
understanding diverse biological processes such as the regulation of imprinted genes, X …
Identification and characterization of a family of mammalian methyl CpG-binding proteins
B Hendrich, A Bird - Genetics Research, 1998 - cambridge.org
We describe the construction, evaluation and application of cDNA libraries from unfertilized
oocytes, and single 2-cell, 4-cell, 7-cell and blastocyst stage embryos. The corresponding …
oocytes, and single 2-cell, 4-cell, 7-cell and blastocyst stage embryos. The corresponding …
Epigenetics: regulation through repression
AP Wolffe, MA Matzke - science, 1999 - science.org
Epigenetics is the study of heritable changes in gene expression that occur without a
change in DNA sequence. Epigenetic phenomena have major economic and medical …
change in DNA sequence. Epigenetic phenomena have major economic and medical …
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin
MeCP2 is an abundant mammalian protein that binds to methylated CpG. We have found
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …
that native and recombinant MeCP2 repress transcription in vitro from methylated promoters …
Alterations in DNA methylation: a fundamental aspect of neoplasia
Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
Mutational inactivation and allelic loss of the von Hippel-Lindau (VHL) gene appear to be
causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that …
causal events for the majority of spontaneous clear-cell renal carcinomas. We now show that …
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice
GL Wolff, RL Kodell, SR Moore… - The FASEB …, 1998 - Wiley Online Library
ABSTRACT 'Viable yellow'(Avy/a) mice are larger, obese, hyperinsulinemic, more
susceptible to cancer, and, on average, shorter lived than their non‐yellow siblings. They …
susceptible to cancer, and, on average, shorter lived than their non‐yellow siblings. They …
Effects of DNA methylation on DNA-binding proteins and gene expression
PH Tate, AP Bird - Current opinion in genetics & development, 1993 - Elsevier
DNA methyltransferase is needed for normal development, perhaps because DNA
methylation plays a part in the control of gene activity. It is clear that the methylation of …
methylation plays a part in the control of gene activity. It is clear that the methylation of …