Melanomas arising in the uveal tract of the eye are a rare form of the disease with a biology
and clinical phenotype distinct from their more common cutaneous counterparts. Treatment …

Simple Summary The mitogen-activated protein kinase/extracellular signal-regulated kinase
(MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the …

The mitogen-activated protein kinase (MAPK) pathway plays a vital role in cellular
processes such as gene expression, cell proliferation, cell survival, and apoptosis. Also …

Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor with a high
lethal rate. Patients who undergo conventional enucleation treatments consistently suffer …

The WNT pathway is one of the major signaling cascades frequently deregulated in human
cancer. While research had initially focused on signal transduction centered on β-catenin as …

HDAC3 is one of the main targets of histone deacetylase (HDAC) inhibitors in clinical
development as cancer therapies, yet the in vivo role of HDAC3 in solid tumors is unknown …

Purpose: Uveal melanoma is the most common eye cancer in adults. Approximately 50% of
patients with uveal melanoma develop metastatic uveal melanoma (mUM) in the liver, even …

Uveal melanoma is the most common type of intraocular cancer with a low mean annual
incidence of 5-10 cases per million. Tumours are located in the choroid (90%), ciliary body …

In the treatment of most malignancies, radiotherapy plays a significant role. However, the
resistance of cancer cells to ionizing radiation (IR) is the main reason for the failure of …

Uveal melanoma (UM) and retinoblastoma (RB), which cause blindness and even death,
are the most frequently observed primary intraocular malignancies in adults and children …