MicroRNAs (miRNAs) are pervasively expressed and regulate most biological functions.
They function by modulating transcriptional and translational programs and therefore they …

The past several years have seen dramatic leaps in our understanding of how gene
expression is rewired at the translation level during tumorigenesis to support the …

To understand the mechanisms that mediate germline genetic leukemia predisposition, we
studied the inherited ribosomopathy Shwachman-Diamond syndrome (SDS), a bone …

The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of
gene expression. This is especially true in the cancer setting, as many oncogenes and …

The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for
gene expression, and occurs principally at the initiation phase which is mainly regulated by …

Elucidating the molecular drivers of human breast cancers requires a strategy that is
capable of integrating multiple forms of data and an ability to interpret the functional …

Naive T cells respond to T cell receptor (TCR) activation by leaving quiescence, remodeling
metabolism, initiating expansion, and differentiating toward effector T cells. The molecular …

The link between perturbations in translational control and cancer etiology is becoming a
primary focus in cancer research. It has now been established that genetic alterations in …

Current understanding of tumor immunosuppressive mechanisms forms the basis for
modern day immunotherapies. Immunoregulatory role of platelets in cancer remains largely …

A wealth of novel findings, including congenital ribosomal mutations in ribosomopathies and
somatic ribosomal mutations in various cancers, have significantly increased our …