Sarcomas are complex mesenchymal neoplasms with a poor prognosis. Their clinical
management is highly challenging due to their heterogeneity and insensitivity to current …

Cytogenetics of Bone and Soft Tissue Tumors [1]. In view of the remarkable developments in
this field since 1994, both in the cytogenetic and particularly in the molecular genetic …

This WHO classification covers tumors of soft tissue and bone including inherited tumor
syndromes. Each entity is extensively discussed with information on clinicopathological …

PURPOSE Intense investigation has reshaped concepts about undifferentiated tumors
occurring in young people (small round-cell tumors). Tumors associated with t (11; 22)(p13; …

Endometrial stromal tumors are divided into three types: benign stromal nodules,
endometrial stromal sarcomas, and undifferentiated endometrial sarcomas. A variety of …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

Abstract EWSR1-CREB1 and EWSR1-ATF1 are gene fusions of which one or both have
now been consistently described in 5 histopathologically and behaviorally diverse …

Abstract Purpose: A specific TLS-CHOP fusion gene resulting from the t (12; 16) is present in
at least 95% of myxoid liposarcomas (MLS). Three common forms of the TLS-CHOP fusion …

Ewing's sarcoma (ES) and primitive neuroectodermal tumor (PNET) are members of a tumor
family consistently associated with chromosomal translocation and functional fusion of the …

As a result of chromosome translocations, the EWS gene is fused to a variety of transcription
factors in human solid neoplasia. In Ewing tumors EWS can be fused to four different …