Our understanding of apolipoprotein A-II (apoA-II) physiology is much more limited than that
of apoA-I. However, important and rather surprising advances have been produced, mainly …

The numerous functions of the liver are controlled primarily at the transcriptional level by the
concerted actions of a limited number of hepatocyte-enriched transcription factors …

Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total
cholesterol, triglycerides or both,, is observed in about 20% of individuals with premature …

The present review summarizes recent advances in the transcriptional regulation of the
human apolipoprotein genes, focusing mostly, but not exclusively, on in-vivo studies and …

Hepatocyte nuclear factor 4α (HNF4α) regulates the expression of many genes preferentially
expressed in liver. HNF4α-null mice die during embryogenesis precluding the analysis of its …

Background Apolipoprotein (apo) A-II is a major structural protein of plasma HDLs, but little
is known regarding its functions. Methods and Results To investigate the physiological role …

Apolipoprotein AII (apoAII) transgenic (apoAIItg) mice exhibit several traits associated with
the insulin resistance (IR) syndrome, including IR, obesity, and a marked …

Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by
elevations in total cholesterol (TC) and low density lipoprotein cholesterol (LDLc) …

To identify regulatory elements in the proximal human ATP-binding cassette transporter A1
(hABCA1) gene promoter we transfected RAW cells with plasmids containing mutations in …

Abstract Upstream stimulatory factor 1 (USF 1), is a transcription factor controlling
expression of several genes involved in lipid and glucose homeostasis and co-localizes with …