The number of molecularly stratified treatment options available to patients with colorectal
cancer (CRC) is increasing, with a parallel rise in the use of biomarkers to guide …

Objectives: To develop evidence-based guideline recommendations through a systematic
review of the literature to establish standard molecular biomarker testing of colorectal cancer …

Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Microsatellites are short tandem repeat DNA sequences of one to tetra base pairs distributed
throughout the human genome, both in coding and non-coding regions. Owing to their …

Microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair (MMR)
system and occurs in approximately 15% of colorectal cancers (CRCs), more frequently in …

Biomarkers currently play an important role in the detection and management of patients
with several different types of gastrointestinal cancer, especially colorectal, gastric, gastro …

Purpose It is uncertain whether modest benefits from adjuvant chemotherapy in stage II
colorectal cancer justify the toxicity, cost, and inconvenience. We investigated the usefulness …

Background Approximately 15% of colorectal cancers develop because of defective function
of the DNA mismatch repair (MMR) system. We determined the association of MMR status …

Microsatellite instability (MSI) is the molecular fingerprint of the deficient mismatch repair
(MMR) system, which characterizes∼ 15% of colorectal cancers. MSI develops as a result of …

BACKGROUND AND METHODS: We have reviewed and pooled data from published
studies to evaluate the relationship between microsatellite instability (MSI) and colorectal …