Metabotropic γ-aminobutyric acid G protein–coupled receptors (GABAB) represent one of
the two main types of inhibitory neurotransmitter receptors in the brain. These receptors act …

Equilibrium fluctuations and triggered conformational changes often underlie the functional
cycles of membrane proteins. For example, transporters mediate the passage of molecules …

Three classes of G-protein-coupled receptor (GPCR) partners–G proteins, GPCR kinases,
and arrestins–preferentially bind active GPCRs. Our analysis suggests that the structures of …

Structural and mechanistic studies on human odorant receptors (ORs), key in olfactory
signaling, are challenging because of their low surface expression in heterologous cells …

The ability to sense external stimuli and dynamically respond lies at the core of cellular
homeostasis. G protein-coupled receptors (GPCRs), the largest family of membrane proteins …

G protein‐coupled receptors (GPCRs) are essential cell membrane signaling molecules and
represent the most important class of drug targets. Some signaling pathways downstream of …

The antidiuretic hormone arginine-vasopressin (AVP) forms a signaling complex with the V2
receptor (V2R) and the Gs protein, promoting kidney water reabsorption. Molecular …

Prostate cancer is a heterogeneous, slow growing asymptomatic cancer that predominantly
affects man. A purinergic G-protein coupled receptor, P2Y1R, is targeted for its therapeutic …

G protein‐coupled receptors (GPCRs) are membrane‐bound proteins that are ubiquitously
expressed in many cell types and take part in mediating multiple signaling pathways …

Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays a hot topic in
medicinal chemistry. Allosteric modulators, ie, compounds which bind in a receptor site …