Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

A characteristic feature of host responses to helminth infections is the development of
profound systemic and tissue-localised Type 2 immune responses that play critical roles in …

Helminth endemic regions report lower COVID-19 morbidity and mortality. Here, we show
that lung remodeling from a prior infection with a lung-migrating helminth, Nippostrongylus …

Type 2 immune responses form a critical defence against enteric worm infections. In recent
years, mouse models have revealed shared and unique functions for group 2 innate …

Immunological memory of innate immune cells, also termed “trained immunity”, allows for
cross-protection against distinct pathogens, but may also drive chronic inflammation. Recent …

When recruited to mammalian tissues, monocytes differentiate into macrophages or
dendritic cells (DCs). In the past few years, the existence of monocyte-derived DCs (moDCs) …

Parasitic helminth infections remain a significant global health issue and are responsible for
devastating morbidity and economic hardships. During infection, helminths migrate through …

The impact of the host immune environment on parasite transcription and fitness is currently
unknown. It is widely held that hookworm infections have an immunomodulatory impact on …

Fungal pathogens are underappreciated causes of significant morbidity and mortality
worldwide. In previous studies, we determined that a heat-killed, Cryptococcus neoformans …

Recent breakthroughs in single-cell sequencing, advancements in cellular and tissue
imaging techniques, innovations in cell lineage tracing, and insights into the epigenome …